MovDisordV3, Main, Exploration, bibRecord, 002B04

Valproate‐induced Parkinsonism in epilepsy patients

Identifieur interne : 002B04 ( Main/Exploration ); précédent : 002B03; suivant : 002B05

Valproate‐induced Parkinsonism in epilepsy patients

Auteurs : Dominic Jamora [Singapour, Philippines] ; Shih-Hui Lim [Singapour] ; Andrew Pan [Singapour] ; Louis Tan [Singapour] ; Eng-King Tan [Singapour]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-01.

RBID : ISTEX:5C2042707E1E7101CF4372C807B6685851A5F6AD

Descripteurs français

Pascal (Inist)
- Acide valproïque, Epilepsie, Homme, Parkinsonisme, Système nerveux pathologie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Anticonvulsants (adverse effects), Chi-Square Distribution, Epilepsy, Epilepsy (drug therapy), Female, Human, Humans, Male, Middle Aged, Nervous system diseases, Parkinsonian Disorders (chemically induced), Parkinsonism, Valproic Acid (adverse effects), Valproic acid, epilepsy, valproate.
MESH :
- chemical , adverse effects : Anticonvulsants, Valproic Acid.
- chemically induced : Parkinsonian Disorders.
- drug therapy : Epilepsy.
- Adult, Chi-Square Distribution, Female, Humans, Male, Middle Aged.

Abstract

We systematically examined 226 epilepsy patients in a tertiary‐referral center and found 6 (5.04%) to have valproate‐induced Parkinsonism. There was a significantly higher prevalence of patients with Parkinsonism in the group of patients treated with valproate compared to those who were on other antiepileptic drugs (6 [5.04%] of 119 vs. 0 [0%] of 107; χ2 = 5.54; P = 0.025). These six patients had been on valproate for more than 3 years (mean, 75.67 ± 25.32 months) at an average dose of 750 ± 273.86 mg/day. The valproate doses were decreased or discontinued with supplementation from another antiepileptic medication. The mean UPDRS motor score significantly improved from 10.67 ± 5.1 to 4.75 ± 2.75 (P < 0.05). There was no relapse of seizures. Clinicians working in tertiary‐referral centers should have a high index of suspicion for valproate‐induced Parkinsonism. Early recognition and switching into another antiepileptic medication may help reduce unnecessary suffering in these patients. © 2006 Movement Disorder Society

Url:

https://api.istex.fr/document/5C2042707E1E7101CF4372C807B6685851A5F6AD/fulltext/pdf

DOI: 10.1002/mds.21188

Affiliations:

Philippines, Singapour

Le document en format XML

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<front><div type="abstract" xml:lang="en">We systematically examined 226 epilepsy patients in a tertiary‐referral center and found 6 (5.04%) to have valproate‐induced Parkinsonism. There was a significantly higher prevalence of patients with Parkinsonism in the group of patients treated with valproate compared to those who were on other antiepileptic drugs (6 [5.04%] of 119 vs. 0 [0%] of 107; χ2 = 5.54; P = 0.025). These six patients had been on valproate for more than 3 years (mean, 75.67 ± 25.32 months) at an average dose of 750 ± 273.86 mg/day. The valproate doses were decreased or discontinued with supplementation from another antiepileptic medication. The mean UPDRS motor score significantly improved from 10.67 ± 5.1 to 4.75 ± 2.75 (P < 0.05). There was no relapse of seizures. Clinicians working in tertiary‐referral centers should have a high index of suspicion for valproate‐induced Parkinsonism. Early recognition and switching into another antiepileptic medication may help reduce unnecessary suffering in these patients. © 2006 Movement Disorder Society</div>
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Movement Disorders (revue)

Valproate‐induced Parkinsonism in epilepsy patients

Valproate‐induced Parkinsonism in epilepsy patients

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.